Optical Coherence Tomography (OCT) is the core device for current ophthalmic clinical diagnosis. Featuring non‑contact, non‑invasive, high‑resolution and real‑time tomographic imaging, it is widely applied in the early screening and diagnosis of glaucoma, macular degeneration, diabetic retinopathy, corneal diseases and other ophthalmic conditions. It also supports preoperative planning and postoperative evaluation for refractive surgery and cataract surgery, serving as essential core equipment in ophthalmic diagnosis and treatment. The high‑voltage drive power supply is a critical supporting component of ophthalmic OCT devices. It delivers high‑precision, high‑stability high‑voltage bias or drive voltage to key optical detection units, including Photomultiplier Tubes (PMTs), Avalanche Photodiodes (APDs), galvanometer scanning drive modules, and acousto‑optic modulators. Its output voltage accuracy, temperature stability, low‑noise performance and long‑term drift directly determine the photoelectric detection sensitivity, imaging resolution, signal‑to‑noise ratio and clinical diagnostic accuracy of OCT systems. Current mainstream spectral‑domain and swept‑source OCT devices require high‑voltage drive power supplies with continuously adjustable output from 0~2000 V, single‑channel voltage control accuracy better than ±0.1 %, temperature coefficient below 5 ppm/°C, peak‑to‑peak output ripple less than 5 mV, and long‑term voltage drift below 0.1 % during 8 hours of continuous operation. Failure to meet these specifications causes unstable photodetector gain, reduced detection sensitivity, degraded OCT image SNR, blurry retinal layer details, and missed opportunities for early disease diagnosis. Traditional high‑voltage power supplies for OCT suffer from low output accuracy, severe temperature drift, high noise and poor long‑term stability, failing to satisfy the high‑resolution imaging demands of premium modern ophthalmic OCT equipment. All designs must strictly comply with IEC 60601‑1 general medical electrical safety standards, IEC 60601‑2‑41 particular safety requirements for ophthalmic optical devices, and GB 9706.1. The products also meet the technical specifications for Class II medical device registration issued by the NMPA. Addressing the core clinical requirements and technical challenges of high‑voltage drive power supplies for ophthalmic OCT equipment, this methodology establishes a comprehensive framework covering topology design, high‑precision output control, full‑range temperature stability optimization, low‑noise output engineering, and medical safety compliance. It accommodates high‑voltage power demands for OCT systems, fundus cameras and ophthalmic laser therapeutic devices, providing standardized design principles to support domestic substitution and performance upgrading of Chinese ophthalmic diagnostic equipment. Focusing on high precision, superior temperature stability and ultra‑low noise required by OCT applications, the methodology adopts a universal architecture of **modular single‑channel inversion + fully digital closed‑loop control + ultra‑low temperature coefficient reference sources**. The system is divided into independent modules: APD/PMT high‑voltage bias power, galvanometer scanner drive power, and acousto‑optic modulator drive power. All modules share one main control platform while maintaining full electrical independence, eliminating crosstalk, temperature drift and poor accuracy typical of conventional centralized high‑voltage power supplies. The design achieves ultra‑precise regulation, minimal thermal drift and ultra‑low noise, fully matching high‑resolution OCT imaging performance. Five core design principles are implemented: First, the APD/PMT bias module uses a flyback quasi‑resonant inverter topology, offering simple structure compact size, galvanic isolation and high voltage gain to achieve continuous 0~2000 V output suitable for PMT and APD biasing. Quasi‑resonant soft switching enables zero‑voltage turn‑on, greatly reducing switching loss, electromagnetic interference and output noise. Optimized high‑frequency ferrite transformers with sandwich winding minimize leakage inductance while multi‑layer insulation satisfies medical isolation requirements for microampere load conditions. Second, galvanometer and acousto‑optic modulator drive modules adopt push‑pull inversion combined with linear regulation, providing bipolar ±200 V~±500 V output with extremely fast dynamic response to support high‑speed scanning. Post‑stage linear regulation ensures ultra‑low ripple and precise voltage stability, improving positioning accuracy, scanning linearity and overall OCT resolution. Third, strict modularization ensures each high‑voltage channel features independent inversion, boosting, rectification, filtering, closed‑loop control and protection circuits with complete electrical isolation and shielding between channels. This eliminates inter‑channel crosstalk, enables flexible channel configuration according to OCT system requirements, and enhances maintainability with independent replaceable units. Fourth, a high‑precision fully digital control platform based on FPGA and low‑drift MCU integrates 16‑bit DAC for fine voltage tuning and 24‑bit ADC for high‑speed accurate sampling. Digital PID closed‑loop regulation guarantees static accuracy better than ±0.1 %. The main controller communicates with the host OCT system for synchronized imaging control and real‑time status monitoring. Fifth, comprehensive low‑drift engineering covers component selection, circuit design and algorithm compensation to stabilize output across the full operating temperature range, ensuring reliable continuous operation in various clinical environments. Full‑range temperature stability optimization forms the core of this methodology. Thermal drift is minimized through three layers: ultra‑low drift component selection, hardware temperature compensation circuits, and full‑range software algorithm correction. Key component specifications include reference sources with temperature coefficient ≤2 ppm/°C and long‑term stability ≤10 ppm/1000 h, metal‑foil sampling resistors ≤5 ppm/°C with ±0.01 % tolerance, low‑leakage high‑voltage rectifiers, low‑drift film capacitors ≤30 ppm/°C, and industrial wide‑temperature operational amplifiers and drive ICs ensuring stable performance from 0 °C to 50 °C. Hardware compensation optimizes reference temperature drift, sampling circuit thermal offset, transformer inductance stability, and integrates high‑precision temperature sensors inside each module to provide real‑time thermal data for algorithm correction. Software compensation builds multi‑point temperature drift models calibrated across 0~50 °C during production. Polynomial fitting creates precise correction tables stored internally. Real‑time algorithms dynamically adjust DAC references and PID parameters according to measured temperatures, restricting overall system temperature drift within ≤3 ppm/°C, significantly exceeding the industry standard of 5 ppm/°C. Long‑term aging compensation further maintains 8‑hour continuous drift below 0.1 % throughout the full service life. High‑precision output and low‑noise optimization ensure ultra‑clean power critical for sensitive photoelectric detection. A 16‑bit DAC achieves fine 0.1 V tuning resolution, while a 24‑bit ADC with ≥10 kHz sampling delivers accurate feedback for fast, stable PID regulation achieving static precision ≤±0.05 %, load regulation ≤±0.1 %, and line regulation ≤±0.05 %. Full‑range factory calibration eliminates systematic errors, with optional user recalibration via upper computer software. Multi‑stage low‑noise design applies quasi‑resonant soft switching to eliminate high‑frequency switching noise outside the OCT detection bandwidth. Three‑stage RC filtering combined with feedthrough suppression reduces peak‑to‑peak ripple to ≤3 mV, surpassing the typical 5 mV industry benchmark. Optimized PCB layout separates power and control grounds, adopting star grounding and differential shielding for sampling circuits. Fully enclosed metal shielding and independent compartmentalization eliminate external interference and internal crosstalk below 0.03 % between channels. Medical safety and reliability comply fully with IEC 60601 series and ophthalmic device regulations with reinforced insulation ≥3 kVAC isolation. Patient leakage current is controlled below 10 μA and equipment leakage below 100 μA. All high‑voltage sections are fully sealed without exposed live parts. Each channel features independent dual hardware/software protection against overvoltage, overcurrent, short circuit, overtemperature and open circuit with response time<1 μs. Fault signals trigger alarms and safe interlocking with the main OCT system to stop scanning under critical conditions. All critical components follow strict medical‑grade derating with voltage stress ≤70 %, current stress ≤60 %, temperature stress ≤80 % of rated values. Full validation including thermal cycling, long‑term aging and vibration testing ensures an MTBF ≥30,000 hours, supporting continuous clinical operation. Complete EMC compliance with GB/T 18268.1 guarantees stable performance in complex hospital electromagnetic environments. In summary, this integrated methodology resolves the traditional limitations of large thermal drift, insufficient accuracy and excessive noise in high‑voltage power supplies for ophthalmic OCT. Combined hardware‑software temperature compensation achieves ≤3 ppm/°C stability, digital closed‑loop control delivers ≤±0.05 % precision, and multi‑stage filtering ensures ultra‑low ripple ≤3 mV. The solution fully satisfies high‑end OCT high‑resolution imaging requirements and can be widely deployed in OCT devices, fundus cameras and ophthalmic laser systems, providing core technical support for the advancement and localization of China’s ophthalmic diagnostic equipment industry.